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Abstract: Introduction: Immune checkpoint-inhibitors (ICIs) improve the survival in certain cancers. However, side e ff ects of ICIs might limit its use. Little is known about their biliary toxicity. Accordingly, we used a large database to investigate the epidemiology of ICI-induced cholangitis and describe underlying associations. Methods: A multi-institutional database (Explorys Inc, Cleveland, OH, USA), ...
Abstract: ff erencebetween Grade 3 (25-50,000/mL) and Grade 2 (50-75,000/mL) (OR 1.75, 0.93-3.29). There was also no di ff erence among severity of thrombocytopenia and bleeding risk when post-biopsy data was isolated. Conclusion: Mostlowriskendoscopicproceduresarelikelysafeintheseverelythrombocytopenicpatient,whenconsideringbleedrisk,andstatisticallysigni fi cantbleedsonlyoccurwithcountslessthan25,000/mL.Diag...
Abstract: Eduard Krishtopaytis, MD1, Prabhat Kumar, MD1, Ashraf Almomani, MD1, Somtochukwu Onwuzo, MD1, Antoine Boustany, MD, MPH1, Dana Alshaikh, MD2, Almaza A. Albakri, MD3, Motasem Alkhayyat, MD1, Imad Asaad, MD4, Khaled Alsabbagh Alchirazi, MD5. Cleveland Clinic Foundation, Cleveland, OH; Mutah University, Amman, Al Karak, Jordan; Royal Jordanian Medical Services, Amman, Al Karak, Jordan; Cleveland Clin...
Abstract: is the between has not been well literature.Precisely, the of on has been con literature. The aim of our study is to determine therisk of GERD and its complications among with hypogonadism and the risk of and its complications with those who with hypogonadism. We Cleveland, OH) includes on...
Abstract: Introduction: Erectile dysfunction (ED) is a well-established comorbidity of In fl ammatory bowel disease (IBD). However, the connection between the two diseases remains unclear. Previous studies have suggested that chronic in fl ammation resulting in endothelial dysfunction maybe a contributing factor in the pathology of ED. Biologics have been shown to decrease in fl ammation among IBD patients. Th...
Abstract: of ustekinumab and vedolizumab on intestinal resection rates in bio-na¨ ı ve CD patients. Methods: A commercial database (Explorys Inc, Cleveland, OH) was utilized, which included electronic health record data from 26 major integrated US healthcare systems. We identi fi ed bio-na¨ ı ve CD patients. The primary outcome was to examine the association between anti-tumor necrosis factor (anti-TNF) medi...
Abstract: showed higher CMV abundance was associated with significantly decreased survival (p50.04) (Figure). When stratified by age, individuals aged$65 with higher CMV abundance had increased overall mortality risk (HR 1.21; p, 0.001) while no significant association was observed between CMV abundance and survival in those aged #55 (Table). Spearman correlation analysis showed intratumoral CMV signatures ...
Abstract: in are of and about are an important aspect of their are to evaluate the and readability of online information related to contraception...
Abstract: Migraine Disorder Occurs More Often in Celiac Disease Patients: A Nationwide Population-Based Cohort Study Andrew Ford, MD1, Manik Aggarwal, MD1, Motasem Alkhayyat, MD1, Almaza A. Albakri, MD2, Abel Joseph, MD1, Claire Jansson-Knodell, MD1, Alberto Rubio Tapia, MD3. Cleveland Clinic Foundation, Cleveland, OH; Royal Jordanian Medical Services, Amman, Al Karak, Jordan; Cleveland Clinic, Cleveland, O...
Abstract: Introduction: In fl ammatory bowel disease(IBD) and Parkinson ’ s disease (PD) are chronic progressive disorders that mainlya ff ect di ff erent organs: the gut and brain,respectively. Increasing evidence supports reciprocalcommunication betweenthe enteric and thecentral nervous system in disease, termed the ’ gut-brainaxis ’ . Biologicshave been shownto decrease in fl ammation among IBD patients howe...
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