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Abstract: Ethanol causes dysregulated muscle protein homeostasis while simultaneously causing hepatocyte injury. Because hepatocytes are the primary site for physiological disposal of ammonia, a cytotoxic cellular metabolite generated during a number of metabolic processes, we determined whether hyperammonemia aggravates ethanol-induced muscle loss. Differentiated murine C2C12 myotubes, skeletal muscle from...
Abstract: With an increase of PhD students working in industry, there is a need to understand what factors are influencing supervision for industrial students. This paper aims at exploring the challenges and good approaches to supervision of industrial PhD students. Data was collected through semi-structured interviews of six PhD students and supervisors with experience in PhD studies at several organizatio...
Abstract: Practitioners struggle with creating and evolving an architecture when developing complex and safety-critical systems in large-scale agile contexts. A key issue is the trade-off between upfront planning and flexibility to embrace change. In particular, the coordination of interfaces is an important challenge, as interfaces determine and regulate the exchange of information between components, subs...
Abstract: This paper identifies three improvement areas related to system design and architecture, where an organization can change to better support continuous integration and continuous delivery: “The product's architecture”, “Ways to work with system design and architecture”, and “The role of the architect”. The three improvement areas are based on a literature review, two series of interviews and a cros...
Abstract: Over the years, a number of approaches have been proposed on the description of systems and software in terms of multiple views represented by models. This modelling branch, so-called multi-view software and system modelling, praises a differentiated and complex scientific body of knowledge. With this study, we aimed at identifying, classifying, and evaluating existing solutions for multi-view mod...
Abstract: Over the years, a number of approaches have been proposed on the description of systems and software in terms of multiple views represented by models. This modelling branch, so-called multi-view software and system modelling, praises a differentiated and complex scientific body of knowledge. With this study, we aimed at identifying, classifying, and evaluating existing solutions for multi-view mod...
Abstract: Based on 25 interviews with participants from four case study companies that develop large‐scale software embedded systems, this paper presents the Test Activity Stakeholders (TAS) model. The TAS model shows how the continuous integration and delivery pipeline can be designed to include test activities that support four stakeholder interests: “Check changes,” “Secure stability,” “Measure progress,...
Abstract: This article endeavors to underpin complexity understanding by scrutinizing how developers experience code complexity and how certain code characteristics impact complexity. The results provide a distinction between essential and accidental code characteristics and help in evaluating the influence of these characteristics on complexity increase....
Abstract: Context: When determining the functions and qualities (a.k.a. requirements) for a system, creativity is key to drive innovation and foster business success. However, creative requirements must be practically operationalized, grounded in concrete functions and system interactions. Requirements Engineering (RE) has produced a wealth of methods centered around goal modeling, in order to graphically e...
Abstract: As researchers and teachers and practitioners, we “software types” excel at multitasking. This, in part, led us to ask the question: Can one attend a software engineering conference and do something good for society? We found the answer to be a resounding yes. In this article, we present our first experience of running RE Cares, a conference collocated event. This event included a workshop, confer...
Abstract: Teaching Distributed Software Development with real distributed settings is a challenging and rewarding task. Distributed courses are idiosyncratically more challenging than standard local courses. We have experienced this during our distributed course, which has been run for 14 consecutive years. In this article, we present and analyze the emerging diversities specific to distributed project-base...
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